Myositis associated with connective tissue disease

The classic ones – Antisynthetase Syndrome

The less well studies ones – Scleromyositis

Werner Stenzel ,Consultant, lecturer of Neuropathology at the Department of Neuropathology, Charité – Universitätsmedizin, Berlin, Germany
Head of the Neuromuscular Diagnostic and Research Unit at the Department of Neuropathology, Charité – Universitätsmedizin, Berlin, Germany
Head of educational program for medical students at the Department of Neuropathology

  • On March 1st

  • 12:00 - 13:00
  • Online Conference

In this seminar, the so-called overlap myositis will be highlighted.

We have applied a new electron microscopical technique called large scale electron microscopy allowing a ‘pan and zoom’ approach similar to ‘google earth’ viewing.

This analysis allows to study >1000 capillaries of patients and controls, highlighting reduplications of basement membranes endothelial activation and pericytes proliferations

We show that this type of ultrastructural changes is specific for a subtype of scleromyositis and discus possible pathogenic mechanisms.

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