Genetics and single cell sequencing to identify new therapeutic targets for cardiovascular diseases

A l'invitation de Stéphane Hatem, directeur de l'UMRS 1166 et directeur général de l'IHU-ICAN, le séminaire mensuel UMRS 1166 - ICAN accueillera

Patrick T. Ellinor, M.D. - Ph.D.
Membre du Broad Institute, Harvard, directeur du Service d'arythmie cardiaque du Massachusets General Hospital et professeur de médecine à la Harvard School of Medicine, membre du consortium MAESTRIA (H2020)

Synopsis : Cardiovascular diseases are the leading causes of death worldwide, yet there is an urgent need for new therapies.  In the current talk, we will discuss three complimentary approaches for the discovery of new therapeutic targets – genetics, machine learning, and single cell sequencing. First, we will review the latest approaches to identify genes underlying cardiovascular diseases using genome wide association studies and large-scale sequencing. We will then discuss the application of machine learning to imaging data to define new cardiovascular traits. Finally, we will explore recent results from single cell sequencing in patients with dilated and hypertrophic cardiomyopathy that has identified a disease-specific upregulation of activated fibroblasts.