It's happening at Sorbonne University

See All

Research and Innovation

Sorbonne University promotes excellence at the core of each of its disciplines and develops numerous interdisciplinary programs capable of meeting the major challenges of the 21st century.

Recherche et Innovation

Education

Discover our entire academic offer

In Arts, Languages, Letters, Human and Social Sciences / Medicine and Health Professions / Science and Engineering

Choosing Sorbonne University means joining a world-renowned multidisciplinary institution, giving the best of oneself to follow a high-level education and join a community of more than 55,000 students and 360,000 alumni worldwide.
 

Study at
Sorbonne University

Participate in the great adventure of learning, succeed in high-level studies and prepare to create the future.

Parismus is the international student association of Sorbonne University

Parismus

Parismus is the international student association of Sorbonne University.

Supporting International Students & Scholars

Sorbonne University supports its international members with a variety of services.

Nous sommes à vos côtés

Bringing together 10 institutions covering offering studies in literature, medicine, science and engineering, technology and management. This diversity fosters a global approach to teaching and research, to jointly promote access to knowledge for all.

Alliance 4EU+

The 4EU+ Alliance

In a changing world, Sorbonne University has joined forces with the universities of Charles in Prague, Heidelberg, Warsaw, Milan and Copenhagen, to create the 4EU+ Alliance.

With an innovative model of European university, six large research-intensive universities work together respond to the educational and research challenges facing Europe.

Les Alliances de Sorbonne Université


Publications

All publications

Parlez-vous (les) français ?

Par Mathieu Avanzi

Atlas des expressions de nos régions

Galilée à la plage

Par Arnaud Cassan

L'astronomie dans un transat

deps
  • Médecine

DREPS – Sickle cell disease : Paris Research Group – Sorbonne University

CRG 25

  • Groupe de recherche clinique

Sickle cell disease is a genetic disorder of hemoglobin leading to anemia by destruction of red blood cells and to microcirculatory dysfunction. It is very common in sub-Saharan Africa, the Maghreb and India, but is also the most common genetic disorder among newborns in France. It causes acute complications (acute painful episode, acute chest syndrome, infections, vascular events) and progressive target organ damage (kidney, heart, brain…).

The sickle cell center of the Tenon Hospital coordinates the multidisciplinary care of over 1,000 adult patients. Research within the center adresses two main areas:

  1. History of chronic complications over the lifetime.
  2. Analysis of the clinincal care pathways, with a focus on emergency visits and hospitalizations.

Director : François Lionnet

Life expectancy of sickle cell patients has dramatically increased thanks to the successful management of severe acute complications. Sickle cell disease is now a chronic disease, and progressive kidney and heart dysfunction has become the prime factor determining life expectancy. Systematic patient follow-up data allows to better understand the natural history of these complications and the factors that determine it. Subgroups at risk may require more frequent monitoring and a stronger focus on preventive interventions.

Director : Olivier Steichen

Acute painful episodes impair the quality of life of sickle cell patients, leading to emergency department visits and subsequent hospitalizations. The use of emergency care varies from one patient to another and for the same patient over time. Hospital and national administrative databases can be used to characterize the patterns of health care use related to sickle cell disease, their frequency and the factors that determine it. Some of these factors, such as psychiatric comorbidities, may benefit from specific interventions to improve patient outcomes.

Direction

  • Olivier Steichen

co-direction

  • François Lionnet
  • Tél. : +33 1 56 01 67 91
  • francois.lionnet@aphp.fr

Coordonnées

Adresse physique

Centre de la drépanocytose Service de médecine interne, Hôpital Tenon, 4 rue de la Chine
75020 Paris

Hopital Tenon
Hopital Tenon