Relations between the nervous system and the respiratory system

Cerebral Cortex and Respiration, Pr Similowski

with the study of the neurophysiological and psychophysiological mechanisms of dyspnea (Pr Morélot-Panzini), the study of the neurophysiology of acute respiratory failure (Pr Demoule), and the development, from a patent portfolio, of a “brain-ventilator” interface (Pr Raux). Also included in this theme are programs such as “Respiratory neurophysiology of phonation” (Pr Gatignol), “Cortical control of postural and respiratory interactions (Dr Attali),” control and respiratory sensations during exercise “(Dr. Laveneziana) or “respiration-cognition interactions” (Pr Similowski).

Automatic control of ventilation

– in animals (Pr Bodineau)

– in humans (Pr Straus)

With pharmacological and biomathematical valences (Brigitte Quenet and Rivals, ESPCI); this research theme particularly targets congenital central alveolar hypoventilation consecutive to mutation of the PHOX2B gene (“Ondine Syndrome”), with constant back and forth interactions between animal models and patients (“rare disease” reference center within the R3S department of the GH Pitié-Salpêtrière). Programs such as “interaction between stress and breathing” (Ms. Sevoz-Couche, CR Inserm) and “interactions between serotonergic systems and sex hormones during obstructive sleep apnea syndrome” (Ms. Fiamma, Dr. Cardot, Dr. Redolfi) are also part of this theme.

Neuroplasticity and respiratory neurostimulation

with a peripheral approach in animals and humans (implanted phrenic stimulation: Prof. Assouad and Pr Gonzalez-Bermejo), a physio-pharmacological medullary approach (Ms Vivodtzev, CR Inserm) and a central approach (inducible respiratory neuroplasticity, Ms. Marie-Cécile Nierat). In this theme, there are projects for the development and physiological and clinical validation of new technological approaches for implanted phrenic stimulation, in classical indications (high tetraplegia, central hypoventilations) and innovative ones (prevention of degenerative or iatrogenic diaphragmatic atrophy-artificial ventilation). There are also various projects evaluating new approaches to the induction of cortical respiratory neuroplasticity for the treatment of central hypoventilations and the treatment of dyspnea.