Nutrition and obesities : systemic approaches
Unité mixte de recherche en santé
Our laboratory is conducting for many basic and translational research in the area of obesity and related metabolic disorders.It has several aims:
- to explore the disturbances of inter-organ dialogue and especially the role of adipose tissue, the intestine and the microbiota in these dialogues
- identifying new ways to stratify the disease and new therapies to improve cardiometabolic health.
Leaders: K. Clément (PU-PH) and J. Aron-Wisnewsky (MCU-PH)
Team Contributors: R. Alili, C. Poitou, S. André, I. Dugail, M. Guerre-Millo, N. Sokolovska, H. Soula
Main collaborators: JD. Zucker, International consortia Metacardis, ePos, Litmus (IMI2), INRA
- Define gut microbiota signature in CMD and evaluate the impact of environment (diet and drugs)
- Demonstrate causality of CMD microbial signature in the development of CMD or its resolution:
- in human interventions: Metacardis follow-up (development), diet or bariatric surgery (reversal)
- in mice: gut microbiota transfer experiments (induce CMD or its reversal)
Leaders : A. Ribeiro (CR INSERM), S. André (MCU SU), P. Serradas (PU SU)
Team contributors : C. Amouyal, L. Genser, A. Leturque, C. Osinski, C. Poitou, H. Soula, F. Andreelli
Main collaborators: P. Collombat (France), U. Meinzer (France), C. Alvarez (Espagne), C. Magnan (France), G. Gorochov (France), R. Regazzi (Suisse), G. Mithieux (France).
The intestine is a target for changes in external (food, microbiota) and internal (immune system) environment. Gut adaptation has in turn consequences on gut immunity, epithelial cells homeostasis and key organs for energy balance.
Leaders : I. Dugail (DR INSERM) and G. Marcelin (Post-doc)
Team Contributors: C. Rouault, C. Gamblin, M. Guerre-Millo, J. Aron-Wisnewsky, F. Marquet, P. Bellassen, K. Clément
Main collaborators: L. Yvan-Charvet (F), E. Gautier (F), G. Desrumeaux (F), A. Fereira (Brasil), F. Charlotte, G. Le Naour, D. Sasson (Inserm F)
- Understand white adipose tissue (WAT) fibrosis : role of progenitors
- Characterize WAT senescence :
- Evaluate inappropriate turnover of subcellular components (Lysosomal degradation)
- Examine PG as gut-derived signaling modulators in AT remodeling
Leaders: N. Sokolovska (MCU SU) and H. Soula (PU SU)
Team contributors: F. Jacques (IE), All team members (link with experimental and clinical approaches).
Main collaborators: JD. Zucker (DR IRD / SU), E. Prifti (IR ICAN), E. Belda (IR, ICAN), Y. Chevaleyre (PU P12), B. Hanczar (PU Evry), P.-H. Wuillemin (LIP6, SU), consortia internationaux (ePos, Metacardis, Litmus)
We will develop innovative tools for data analysis, physiological status prediction, and visualisation in metabolic diseases. Convergence of techniques include statistical inferences, machine learning, and mechanistic approach using dynamical systems. This WP is strongly integrated with the other WPs which produce large-scale data.
Leaders: C. Poitou (PU-PH) and J. Aron-Wisnewsky (MCU-PH)
Team Contributors: K. Clément, P. Tounian, B. Dubern, F. Marchelli, F. Marchelli, L. Genser
Main collaborators: M. Tauber (F), S. Farooqi (UK), A. Rudich (Israel), P. Kuhnen (G)
- Develop innovative diagnosis and predictive factors/tools
- for patient stratification
- to predict poor responders’ outcomes after interventions (diet or bariatric surgery) or after treatment in genetic obesities
- discover new mutation/genes/pathways in rare obesities
- Develop novel approaches for therapy with personalized medicine
- improve the outcomes of poor responder’s response by adding other specific interventions (physical activity, specific diet, pre or prebiotic that modulates gut microbiota)
- implement new treatments in rare obesities
- Institut National de la Santé et de la Recherche Médicale | INSERM
- Sorbonne Université