It's happening at Sorbonne University

See All

Research and Innovation

Sorbonne University promotes excellence at the core of each of its disciplines and develops numerous interdisciplinary programs capable of meeting the major challenges of the 21st century.

Recherche et Innovation


Discover our entire academic offer

In Arts, Languages, Letters, Human and Social Sciences / Medicine and Health Professions / Science and Engineering

Choosing Sorbonne University means joining a world-renowned multidisciplinary institution, giving the best of oneself to follow a high-level education and join a community of more than 55,000 students and 360,000 alumni worldwide.

Study at
Sorbonne University

Participate in the great adventure of learning, succeed in high-level studies and prepare to create the future.

Parismus is the international student association of Sorbonne University


Parismus is the international student association of Sorbonne University.

Supporting International Students & Scholars

Sorbonne University supports its international members with a variety of services.

Nous sommes à vos côtés

Bringing together 10 institutions covering offering studies in literature, medicine, science and engineering, technology and management. This diversity fosters a global approach to teaching and research, to jointly promote access to knowledge for all.

Alliance 4EU+

The 4EU+ Alliance

In a changing world, Sorbonne University has joined forces with the universities of Charles in Prague, Heidelberg, Warsaw, Milan and Copenhagen, to create the 4EU+ Alliance.

With an innovative model of European university, six large research-intensive universities work together respond to the educational and research challenges facing Europe.

Les Alliances de Sorbonne Université


All publications

Parlez-vous (les) français ?

Par Mathieu Avanzi

Atlas des expressions de nos régions

Galilée à la plage

Par Arnaud Cassan

L'astronomie dans un transat

  • Médecine

Nutrition and obesities : systemic approaches

MRSU 1269

  • Équipe d'accueil

Our laboratory is conducting for many basic and translational research in the area of obesity and related metabolic disorders.It has several aims:

  • to explore the disturbances of inter-organ dialogue and especially the role of adipose tissue
  • identifying new ways to stratify the disease and new therapies to improve cardiometabolic health.


Leaders: K. Clément (PU-PH) and J. Aron-Wisnewsky (MCU-PH)
Team Contributors: R. Alili, C. Poitou, S. André, I. Dugail, M. Guerre-Millo, N. Sokolovska, H. Soula
Main collaborators: JD. Zucker, International consortia Metacardis, ePos, Litmus (IMI2), INRA

Main Objectives

  • Define gut microbiota signature in CMD and evaluate the impact of environment (diet and drugs)
  • Demonstrate causality of CMD microbial signature in the development of CMD or its resolution:
    • in human interventions: Metacardis follow-up (development), diet or bariatric surgery (reversal)
    • in mice: gut microbiota transfer experiments (induce CMD or its reversal)


Leaders : A. Ribeiro (CR INSERM), S. André (MCU SU), P. Serradas (PU SU)
Team contributors : C. Amouyal, L. Genser, A. Leturque, C. Osinski, C. Poitou, H. Soula, F. Andreelli
Main collaborators: P. Collombat (France), U. Meinzer (France), C. Alvarez (Espagne), C. Magnan (France), G. Gorochov (France), R. Regazzi (Suisse), G. Mithieux (France).

Main Objectives

The intestine is a target for changes in external (food, microbiota) and internal (immune system) environment. Gut adaptation has in turn consequences on gut immunity, epithelial cells homeostasis and key organs for energy balance.


Leaders : I. Dugail (DR INSERM) and G. Marcelin (Post-doc)
Team Contributors: C. Rouault, C. Gamblin, M. Guerre-Millo, J. Aron-Wisnewsky, F. Marquet, P. Bellassen, K. Clément
Main collaborators: L. Yvan-Charvet (F), E. Gautier (F), G. Desrumeaux (F), A. Fereira (Brasil), F. Charlotte, G. Le Naour, D. Sasson (Inserm F)

Main Objectives

  • Understand white adipose tissue (WAT) fibrosis : role of progenitors
  • Characterize WAT senescence :
    • Evaluate inappropriate turnover of subcellular components (Lysosomal degradation)
    • Examine PG as gut-derived signaling modulators in AT remodeling


Leaders: N. Sokolovska (MCU SU) and H. Soula (PU SU)
Team contributors: F. Jacques (IE), All team members (link with experimental and clinical approaches).

Main collaborators: JD. Zucker (DR IRD / SU), E. Prifti (IR ICAN),  E. Belda (IR, ICAN), Y. Chevaleyre (PU P12), B. Hanczar (PU Evry), P.-H. Wuillemin (LIP6, SU), consortia internationaux (ePos, Metacardis, Litmus)

Main Objectives

We will develop innovative tools for data analysis, physiological status prediction, and visualisation in metabolic diseases. Convergence of techniques include statistical inferences, machine learning, and mechanistic approach using dynamical systems. This WP is strongly integrated with the other WPs which produce large-scale data.  


Leaders: C. Poitou (PU-PH) and J. Aron-Wisnewsky (MCU-PH)
Team Contributors: K. Clément, P. Tounian, B. Dubern, F. Marchelli, F. Marchelli, L. Genser
Main collaborators: M. Tauber (F), S. Farooqi (UK), A. Rudich (Israel), P. Kuhnen (G)

Main Objectives

  • Develop innovative diagnosis and predictive factors/tools 
    • for patient stratification
    • to predict poor responders’ outcomes after interventions (diet or bariatric surgery) or after treatment in genetic obesities
    • discover new mutation/genes/pathways in rare obesities
  • Develop novel approaches for therapy with personalized medicine
    • improve the outcomes of poor responder’s response by adding other specific interventions (physical activity, specific diet, pre or prebiotic that modulates gut microbiota)
    • implement new treatments in rare obesities


  • Karine Clément

Autres tutelles

  • Institut National de la Santé et de la Recherche Médicale | INSERM
  • Sorbonne Université


Adresse physique

UMRS 1269 Faculté de Médecine Sorbonne Université 91 boulevard de l’Hôpital
75013 Paris

Adresse postale

UMRS 1269 Faculté de Médecine Sorbonne Université 91 boulevard de l’Hôpital
75013 Paris